Evolution of signaling networks
The main question that drives this research line is understanding how specific genetic circuits evolve, in contrast with the evolution of single genes. What are the forces and constraints that shape differences between species, in developmental processes?
As an example, we are focusing on the evolution of DELLAs and their associated transcription factors -given the particular role of these proteins as 'hubs' in transcriptional circuits. We are also studying how several circuits involved in vascular differentiation have emerged during evolution.
In our research, we combine genomic, phylogenetic, and molecular genetic approaches in species like Arabidopsis thaliana, Solanum lycopersicum, Oryza sativa and the liverwort Marchantia polymorpha.
We have set up a BLAST server [accessible only from UPV campus] with the genomes of representative species along the green lineages:
Our selected papers
Hernández-García J, Sun R, Serrano-Mislata A, Inoue K, Vargas-Chávez C, Esteve-Bruna D, Arbona V, Yamaoka S, Nishihama R, Kohchi T, Blázquez MA.
Curr. Biol. (2021) doi: 10.1016/j.cub.2021.06.010.
Origin and evolution of gibberellin signaling and metabolism in plants
Hernández-García J, Briones-Moreno A, Blázquez MA.
Semin. Cell. Dev. Biol. (2021) 109, 46-54.
Evolution of hormone response pathways
Blázquez MA, Nelson DC, Weijers D
Origin of gibberellin-dependent transcriptional regulation by molecular exploitation of a transactivation domain in DELLA proteins
Hernández-García J, Briones-Moreno A, Dumas R, Blazquez MA
Conservation of thermospermine synthase activity in vascular and non-vascular plants
Solé-Gil A, Hernández-García J, López-Gresa MP, Blázquez MA, Agustí J
Evolutionary analysis of DELLA-associated transcriptional networks
Briones-Moreno A, Hernández-García J, Vargas-Chávez C, Romero-Campero, F, Romero JM, Valverde F, Blázquez MA
Front. Plant Sci. (2017) 8, 626.
Transcriptional diversification and functional conservation between DELLA proteins in Arabidopsis
Gallego-Bartolomé J, Minguet EG, Marin JA, Prat S, Blázquez MA, Alabadí D
Mol. Biol. Evol. (2010) 27, 1247-1256.
Evolutionary diversification in polyamine biosynthesis
Minguet EG, Vera-Sirera F, Marina A, Carbonell J, Blázquez MA
Mol. Biol. Evol. (2008) 25, 2119-2128.
EVOLUTION OF SIGNALING NETWORKS